Bioreactor Sparger

Lingaliro la Sparge Tube Design Idea

Ma bioreactors ang'onoang'ono amatha kugawa mpweya wabwino ndikuchotsa mpweya woipa popanda nebulizer. Komabe, njirazi sizimagwira ntchito kwa ma bioreactors akuluakulu, popeza kutsika kwapansi mpaka kuchuluka kwa kuchuluka kumabweretsa kuchuluka kwa carbon dioxide ndikulepheretsa kulowa kwa oxygen. Choncho, nebulizers ndi zofunika kuyambitsa mpweya ndi kuchotsa mpweya woipa.

Machitidwe okhala ndi ma nebulizer ang'onoang'ono ndi akulu nthawi zambiri amakhala othandiza chifukwa amatha kukwaniritsa zosowa zosiyanasiyana. Mwachitsanzo, ma nebulizers akuluakulu amapanga thovu lalikulu lomwe limachotsa bwino CO 2 yosungunuka kuchokera mu yankho, koma thovu lalikulu limafuna chipwirikiti champhamvu kuti chiphwanye ndikutulutsa mpweya.

Ngakhale kuti izi zitha kugwira ntchito bwino pama cell olekerera kuzizira, kugwedezeka kumatha kuwononga maselo osalimba anyama. Pazifukwa izi, macro-distributor otsika amatha kugwiritsidwa ntchito poyamba kuchotsa CO 2 ndiyeno micro-distributor mu mndandanda kuti apange thovu zing'onozing'ono zomwe zimapereka mpweya wabwino.

Sintered Porous Metal Sparger Amapanga

Malo Ophatikizana Amawonjezeka Koma Kukula kwa Nthunzi Kuchepa

Chovuta: Mawonekedwe a Bubble Dziwani Mayendedwe a O2 ndi CO 2 Miyezo Yotulutsa Nthunzi

Mapangidwe ndi kukula kwake kumakhudza kwambiri momwe mpweya umabalalitsira mu bioreactor yonse. Makhalidwe a Bubble amakhudzidwa kwambiri ndi kukula ndi kugawa kwa pore, zinthu zogawa, kuthamanga kwamadzi, madzi ndi mpweya, komanso kuthamanga. Mwachitsanzo, zopopera mankhwala ang'onoang'ono zimatulutsa tinthu ting'onoting'ono tozungulira, pomwe zopopera zazikulu zimatulutsa thovu lokulirapo komanso losafanana.

Ma sparger ang'onoang'ono amapanga thovu laling'ono komanso lozungulira, ndipo kugwedezeka kwapamtunda ndiye mphamvu yayikulu pamene akudutsa mu bioreactor. Choncho, amakhala nthawi yaitali mu riyakitala, amene bwino kutengerapo mpweya, koma si oyenera kuchotsa mpweya woipa mu chikhalidwe.

Ma nebulizers akuluakulu amapanga thovu lokhala ndi mainchesi pafupifupi 1-4 mm, pomwe kugwedezeka kwamadzi ndi kusungunuka kwa msuzi kumaphatikizana kuti zikhudze mawonekedwe awo ndikuyenda. Ma thovuwa amakhala ndi nthawi yocheperako yokhalamo koma satha kusungunuka ngati tinthu tating'onoting'ono. Komabe, ma sparger ang'onoang'ono amathanso kutulutsa thovu lalikulu la asymmetric, ndi mphamvu zopanda mphamvu zomwe zimayang'anira machitidwe awo. Ma thovu amenewa amatha kuphulika mosavuta popanda kusungunuka kapena kuvula CO2.

Maonekedwe ndi kukula kwa thovu zimatsimikizira kuchuluka kwa kumeta ubweya wa khungu lomwe selo lidzakumana nalo, mphamvu ya kuchotsa CO 2 kuchokera ku dongosolo, ndi kuchuluka kwa mpweya wokwanira ku selo. Chifukwa chake, ndikofunikira kukhathamiritsa bioreactor nebulizer kuonetsetsa kuti thovu la okosijeni ndi yunifolomu kukula ndi kugawa ndipo siziwononga maselo.

Yankho: Gwiritsani Ntchito Ulamuliro Wokhwima Wopanga Wa HENGKO Bioreactor Sparger

HENGKO ali ndi zaka zopitilira makumi awiri zakubadwa ndikupanga sintered sparger. Sparger yathu yachitsulo chosapanga dzimbiri ndi zotsatira za mainjiniya ambiri omwe nthawi zambiri amawongolera njira yopangira kuti apange chinthu chapamwamba kwambiri chokhala ndi pores yunifolomu, motero, kukula kwa yunifolomu komwe kumatulutsidwa mu bioreactor. Ma spargers athu a porous akulimbikitsidwa kuti agwiritsidwe ntchito ndi owongolera otsika otsika.

Momwe mungagwiritsire ntchito:Wowongolera otsika kwambiri amatulutsa mpweya pang'onopang'ono mu porous sparger. Ma spargers satulutsa mpweya nthawi yomweyo. M'malo mwake, kupanikizika kumawonjezeka pang'onopang'ono mpaka kufika povuta kwambiri, pamene ming'oma imatulutsidwa pang'onopang'ono mu bioreactor.

Pogwiritsa ntchito njira iyi, kuchuluka kwa mpweya wa okosijeni kumatha kusinthidwa kuti muzitha kutulutsa thovu mu bioreactor. Mabowo a sparger ndi ang'onoang'ono kotero kuti thovu lipanga modziwikiratu. Chifukwa chake, ukadaulo wa bioreactor sparging ukhoza kuchulukirachulukira m'miyeso yonse ya zombo, ndi kutengera kwa oxygen molingana ndi kuchuluka kwa gasi.

Mafunso Okhudza Bioreactor Sparger

1. Kodi Sparger mu Bioreactor ndi chiyani?

Mwachidule, sparger ndi chipangizo chomwe chimagwiritsidwa ntchito mu bioreactor kulowetsa mpweya, monga mpweya kapena mpweya, mumadzimadzi. Ntchito yayikulu ya sparger ndikupereka mpweya kwa tizilombo tating'onoting'ono ta bioreactor, zomwe ndizofunikira kuti zikule ndi metabolism.

Sparger mu bioreactor amagwiritsidwa ntchito kuwonjezera mpweya monga mpweya, mpweya, kapena mpweya wina wofunikira pakukula ndi kagayidwe ka tizilombo toyambitsa matenda. Mpweya umaperekedwa ku tizilombo tating'onoting'ono kudzera mu Sparger, zomwe zimathandiza kusunga mpweya wosungunuka mumadzimadzi. Miyezo ya okosijeni yosungunuka ndi gawo lofunikira loyang'anira ndikuwongolera panthawi ya bioprocess chifukwa imakhudza mwachindunji kakulidwe ndi kagayidwe kazachilengedwe.

Sparger idapangidwa kuti iwonetsere gasi mu sing'anga yamadzimadzi m'njira yoyendetsedwa bwino, monga kudzera muzinthu zopangira porous kapena machubu. Sparger ikhoza kukhala pansi kapena pamwamba pa bioreactor, malingana ndi mapangidwe a bioreactor ndi mtundu wa tizilombo tomwe timagwiritsidwa ntchito. Sparger imatha kusinthidwa kuti ipereke kuchuluka kwa mpweya womwe mukufuna komanso kusunga mulingo woyenera wa okosijeni wosungunuka mkatikati.

Sparger imagwiranso ntchito yofunikira pakusunga kuchuluka kwa kusamutsa kwa misa, komwe ndi kuchuluka komwe mpweya umasamutsidwa kuchokera ku gawo la gasi kupita ku gawo lamadzimadzi. Kuchuluka kwa kusamutsa kumatha kukhudzidwa ndi zinthu monga kukula ndi mawonekedwe a bioreactor, mtundu ndi kuchuluka kwa tizilombo tating'onoting'ono, komanso kutentha ndi pH yapakati. Sparger atha kugwiritsidwa ntchito kuwongolera izi ndikuwongolera kuchuluka kwa kusamutsa kwa anthu ambiri, zomwe ndizofunikira kuti bioprocess ipambane.

Mwachidule, ntchito yaikulu ya sparger mu bioreactor ndi kupereka mpweya kwa tizilombo tating'onoting'ono mu madzi sing'anga, zomwe ndi zofunika kuti kukula ndi kagayidwe kawo, ndi kusunga oyenera kusungunuka mpweya milingo ndi misa kutengerapo mlingo, amene ali zofunika kupambana kwa bioprocess.

Kodi Sparger Amatanthauza Chiyani?

Sparger ndi chipangizo chomwe chimagwiritsidwa ntchito polowetsa mpweya m'madzi. Amagwiritsidwa ntchito kwambiri m'ma bioreactors, omwe ndi zida zapadera zomwe zimagwiritsidwa ntchito kulima tizilombo toyambitsa matenda kapena ma cell omwe amalamulidwa.

Kodi Sparger amagwira ntchito bwanji?

Ntchito ya sparger ndi kupereka mpweya kapena mpweya wina kwa bioreactor kuti zithandizire kukula ndi kagayidwe ka maselo kapena tizilombo toyambitsa matenda.

Kodi Sparger Amagwiritsidwa Ntchito Bwanji mu Bioreactor Fotokozani Mitundu Yake?

Pali mitundu ingapo ya spargers yomwe ingagwiritsidwe ntchito mu bioreactor. Izi zikuphatikizapo spargers, zomwe zimapanga mtsinje wamadzimadzi mosalekeza, ndi spargers, zomwe zimamwaza mpweya ngati nkhungu yabwino. Mitundu ina ya ma spargers ndi ma spargers a porous ndi spagers a hollow-fiber.

Kodi Sparger Ili Kuti ku Bioreactor?

Sparger nthawi zambiri imakhala pansi pa bioreactor, pomwe imatha kusakaniza bwino mpweya ndi madzi. M'njira zazikulu zowotchera, ma bubble spargers amagwiritsidwa ntchito chifukwa ndi osavuta komanso otsika mtengo kugwira ntchito.

Ndi Mtundu Uti wa Sparger Umagwiritsidwa Ntchito Kwambiri Pakuwotchera Kwakukulu?

M'njira zazikulu zowotchera, ma bubble spargers amagwiritsidwa ntchito chifukwa ndi osavuta komanso otsika mtengo kugwira ntchito. Bubble sparger imakhala ndi chubu kapena chitoliro chokhala ndi mabowo ang'onoang'ono kapena mipata yomwe mpweya umalowetsedwa mumadzimadzi. Mpweya umayenda m'mabowo kapena mipata ndikupanga mtsinje wopitilira wa thovu mumadzimadzi. Ma Bubble spargers amagwira ntchito popereka mpweya wambiri ku bioreactor ndipo amatha kusinthidwa mosavuta kuti aziwongolera kuchuluka kwa gasi. Komanso ndi zosavuta kuyeretsa ndi kukonza. Komabe, ma bubble spargers amatha kupanga thovu lalikulu lomwe silingakhale lothandiza popereka malo apamwamba kuti ma cell kapena tizilombo toyambitsa matenda tigwirizane ndi mpweya. Nthawi zina, sparger kapena mtundu wina wa sparger ukhoza kukhala woyenera kwambiri panjira inayake yowotchera.

Kodi Muyenera Kudziwa Chiyani Zokhudza Sparger System?

Pali zinthu zingapo zomwe muyenera kuziganizira mukamagwiritsa ntchito sparger mu bioreactor. Izi zikuphatikizapo:

1. Kuwongolera:Ndikofunikira kuwongolera bwino kuchuluka kwa gasi yemwe akulowetsedwa mu bioreactor. Izi zidzaonetsetsa kuti mpweya wolondola ukuperekedwa ku maselo kapena tizilombo tating'onoting'ono komanso kuti mpweya wa okosijeni mu bioreactor uli mkati mwa zomwe mukufuna.

2. Kukhazikika kwa oxygen:Mpweya wa okosijeni mu bioreactor uyenera kuyang'aniridwa pafupipafupi kuti zitsimikizire kuti zili mkati mwazofunikira za ma cell kapena tizilombo tomwe timalimidwa. Ngati mpweya wa okosijeni uli wochuluka kapena wotsika kwambiri, ukhoza kukhudza kukula ndi kagayidwe ka maselo kapena tizilombo toyambitsa matenda.

3. Kupewa kuipitsidwa:Ndikofunika kuwonetsetsa kuti sparger ndi malo ozungulira amatsukidwa bwino ndikusungidwa kuti asaipitsidwe ndi bioreactor. Izi zingaphatikizepo kusintha zosefera za gasi pafupipafupi ndikuyeretsa sparger ndi madera ozungulira ndi mankhwala oyenera ophera tizilombo.

4. Mtengo wa gasi:Kuthamanga kwa gasi kuyenera kusinthidwa momwe kungafunikire kusunga mpweya wofunikira mu bioreactor. Kuthamanga kungafunike kuchulukitsidwa kapena kuchepetsedwa kutengera kuchuluka kwa okosijeni m'maselo kapena tizilombo tating'onoting'ono komanso kuchuluka kwa gasi.

5. Kusamalira:Kukonza nthawi zonse kwa sparger system ndikofunikira kuti iwonetsetse kuti ikugwira ntchito moyenera komanso moyenera. Izi zingaphatikizepo kuyang'ana ngati pali kudontha, kukonzanso zida zowonongeka kapena zowonongeka, ndi kuyeretsa siponji ndi malo ozungulira ngati pakufunika.

2. Ntchito Yaikulu ya Sparger mu Bioreactor?

Ntchito yaikulu ya sparger mu bioreactor ndikulowetsa mpweya, monga mpweya kapena mpweya, mumadzimadzi. Ndikofunikira kuti kukula ndi kagayidwe ka tizilombo tating'onoting'ono ta bioreactor, chifukwa zimafunikira mpweya wopumira. Sparger imathandiza kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda komanso timasunga mpweya wabwino mu bioreactor kuti zithandizire kukula kwawo ndi kagayidwe kake, zomwe ndizofunikira kuti bioprocess ipambane.

A: Kutulutsa mpweya:Ntchito yaikulu ya sparger mu bioreactor ndikulowetsa mpweya, monga mpweya kapena mpweya, mumadzimadzi. Zimathandiza kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda.

B: Kusunga mpweya wosungunuka:Sparger imathandiza kusunga mpweya wosungunuka mumadzimadzi. Miyezo iyi ndi gawo lofunikira loyang'anira ndikuwongolera panthawi ya bioprocess chifukwa imakhudza mwachindunji kukula ndi kagayidwe kazachilengedwe.

C: Kuwongolera kuchuluka kwa gasi:Sparger idapangidwa kuti ipangitse gasi mu sing'anga yamadzimadzi mowongolera. Sparger imatha kusinthidwa kuti ipereke kuchuluka kwa mpweya womwe mukufuna komanso kusunga mulingo woyenera wa okosijeni wosungunuka mkatikati.

D: Kusunga kuchuluka kwa kusamutsa:Sparger imagwiranso ntchito yofunikira pakusunga kuchuluka kwa kusamutsa, komwe ndi kuchuluka komwe mpweya umasamutsidwa kuchokera ku gawo la gasi kupita ku gawo lamadzimadzi.

E: Kukometsa bioprocess:Sparger itha kugwiritsidwa ntchito kuwongolera zinthu monga kukula ndi mawonekedwe a bioreactor, mtundu, ndi kuchuluka kwa tizilombo tating'onoting'ono, komanso kutentha ndi pH yapakati, kukhathamiritsa bioprocess.

F: Kupereka Kusakaniza:Spargers amathandizanso kupanga chisakanizo chofanana chamadzimadzi ndi gasi popereka zosakaniza. Zimathandiza kuti tizilombo toyambitsa matenda tizikhala ndi malo ofanana.

3. Mitundu ya Sparger mu bioreactor?

Mitundu ingapo ya ma spargers ndi ma spargers amiyala omwe amapangidwa ndi zinthu zaporous monga ceramic kapena sintered metal ndi bubble columns spargers, zomwe zimagwiritsa ntchito machubu kapena nozzles kulowetsa mpweya mumadzimadzi.

Mitundu ingapo ya spargers ingagwiritsidwe ntchito mu bioreactor, kuphatikiza:

1. Ziphuphu zamwala:Izi zimapangidwa ndi zinthu zaporous monga ceramic kapena sintered zitsulo ndipo zimayikidwa pansi pa bioreactor. Amapereka malo akuluakulu osinthira gasi ndipo amagwiritsidwa ntchito kwambiri pama bioreactor ang'onoang'ono.

2. Ziphuphu zamtundu wa Bubble:Izi zimagwiritsa ntchito machubu angapo kapena ma nozzles kuti alowetse gasi mumadzimadzi. Atha kuyikidwa pansi kapena pamwamba pa bioreactor ndipo amagwiritsidwa ntchito kwambiri m'ma bioreactor akuluakulu.

3. mphete sparger:Izi zimayikidwa pansi pa bioreactor ndikugwiritsa ntchito mawonekedwe owoneka ngati mphete kuti apange thovu komanso kupereka mpweya wabwino.

4. Micro-bubble Sparger:Izi zapangidwa kuti zipange thovu ting'onoting'ono lomwe limapereka mphamvu yotumizira mpweya wabwino kwambiri ndipo amagwiritsidwa ntchito kwambiri m'ma bioreactors akuluakulu, okwera kwambiri.

5. Jet sparger:Izi zimagwiritsa ntchito ma nozzles kuti alowetse gasi mumadzimadzi. Zitha kuikidwa pansi kapena pamwamba pa bioreactor ndipo zimagwiritsidwa ntchito kwambiri muzomera zamtundu wapamwamba.

6. Paddlewheel sparger:Sparger wamtunduwu amagwiritsa ntchito gudumu lozungulira lopalasa kuti apange thovu komanso kupereka mpweya. Amagwiritsidwa ntchito kwambiri mu njira zowotchera.

Izi ndi zina mwa mitundu ya sparger yomwe imagwiritsidwa ntchito kwambiri mu bioreactors, ndipo kusankha kwa Sparger kumadalira kukula, mtundu, ndi kapangidwe ka bioreactor ndi bioprocess yomwe ikugwiritsidwa ntchito.

4. Momwe Mungakhazikitsire Magawo a Sparging mu Bioreactor?

Kuchuluka kwa mpweya mu bioreactor nthawi zambiri kumakhazikitsidwa kutengera kuchuluka kwa mpweya wa tinthu tating'onoting'ono, kuchuluka kwa gasi, komanso kuchuluka kwa gasi. Zinthu zomwe zingakhudze kuchuluka kwa sparging zimaphatikizapo kukula ndi mawonekedwe a bioreactor, mtundu ndi kuchuluka kwa tizilombo tating'onoting'ono, komanso kutentha ndi pH yapakati.

5. Udindo wa Sparger mu Bioreactor?

Ntchito ya sparger mu bioreactor ndikulowetsa mpweya, monga mpweya kapena mpweya, mumadzi amadzimadzi kuti zigwirizane ndi kufunikira kwa okosijeni wa tizilombo. Ndikofunikira pakukula ndi kagayidwe kake ka tizilombo toyambitsa matenda ndipo, pamapeto pake, kuti bioprocess ipambane.

Sparger imathandiza kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Zimathandiza kusunga mpweya wosungunuka m'madzi amadzimadzi, omwe ndi ofunika kwambiri kuti ayang'anire ndikuwongolera panthawi ya bioprocess monga momwe amakhudzira kukula ndi kagayidwe ka tizilombo toyambitsa matenda.

Sparger idapangidwa kuti iwonetsere gasi mu sing'anga yamadzimadzi m'njira yoyendetsedwa bwino, monga kudzera muzinthu zopangira porous kapena machubu. Sparger ikhoza kukhala pansi kapena pamwamba pa bioreactor, malingana ndi mapangidwe a bioreactor ndi mtundu wa tizilombo tomwe timagwiritsidwa ntchito. Sparger imatha kusinthidwa kuti ipereke kuchuluka kwa mpweya womwe mukufuna komanso kusunga mulingo woyenera wa okosijeni wosungunuka mkatikati.

Sparger imagwiranso ntchito yofunikira pakusunga kuchuluka kwa kusamutsa kwa misa, komwe ndi kuchuluka komwe mpweya umasamutsidwa kuchokera ku gawo la gasi kupita ku gawo lamadzimadzi. Kuchuluka kwa kusamutsa kumatha kukhudzidwa ndi zinthu monga kukula ndi mawonekedwe a bioreactor, mtundu ndi kuchuluka kwa tizilombo tating'onoting'ono, komanso kutentha ndi pH yapakati. Sparger atha kugwiritsidwa ntchito kuwongolera izi ndikuwongolera kuchuluka kwa kusamutsa kwa anthu ambiri, zomwe ndizofunikira kuti bioprocess ipambane.

Sparger imathandizanso kupanga chisakanizo chofanana chamadzimadzi ndi gasi popereka zosakaniza. Zimathandiza kuti tizilombo toyambitsa matenda tizikhala ndi malo ofanana.

Mwachidule, ntchito ya sparger mu bioreactor ndikupereka mpweya kwa tizilombo tating'onoting'ono tating'onoting'ono tamadzimadzi, zomwe ndizofunikira kuti zikule komanso kagayidwe kawo, komanso kusunga milingo yoyenera ya okosijeni yosungunuka komanso kusuntha kwa misa, komwe kuli kofunikira pakukula kwawo. kupambana kwa bioprocess. Zimathandizanso kupanga osakaniza homogenous ndi amapereka kusakaniza kanthu kwa sing'anga madzi.

Ndi mtundu wanji wa Bioreactor Sparger womwe mukufuna kugwiritsa ntchito kapena Sinthani Mwamakonda Anu?

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